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| Products >> Antibodies、Peptides >> Primary antibodies |
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| Anti-eIF4EBP1 (phospho T70) antibody crn-0025R |
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- Product ID crn-0025R
- English name Anti-eIF4EBP1 (phospho T70) antibody
- Product Price 100µg ＄ 620
- Immunogen Synthetic phosphopeptide derived from human eIF4EBP1 around the phosphorylation site threonine 70 .
Reacts with Hu, Ms, Rat
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Raised in |
Rabbit |
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Clonality |
Polyclonal |
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Isotype |
IgG |
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Purity |
Immunogen affinity purified |
- Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
- Form Lyophilized or Liquid
Concentration 1.000 mg/ml
Recommended dilutions ELISA: Use at an assay dependent dilution(1:1000-5000) .
- WB: 1/100 - 1/1000.
- Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Function |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
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Sequence similarities |
Belongs to the eIF4E-binding protein family. |
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Post-translational
modifications |
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR. | All eukaryotic cells express Actin, which often constitutes as much as 50% of
total cellular protein. Actin filaments can form both stable and labile structures
and are crucial components of microvilli and the contractile apparatus of muscle |
| Prev：Anti-eIF4EBP1/4EBP1 Next：Anti-eIF5A antibody |
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