Product ID                                    crn-0032R

Product name                              Anti-alpha 1 Antichymotrypsin antibody

Product Price                               100µg  $320   
Immunogen                                Synthesized phosphopeptide derived from human AACT-Alpha1 C-terminus.

Reacts with                                   hu

Raised in	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purity	Immunogen affinity purified

Storage buffer                               Preservative: 0.02% Sodium Azide

                                                        Constituents: 1% BSA, PBS, pH 7.4

Form                                               Lyophilized or Liquid  
Concentration                              1.000 mg/ml  
Recommended dilutions          ELISA: Use at an assay dependent dilution(1:1000-5000) .
                                                        ICC: Use at an assay dependent dilution(1:50-500).
                                                        ICC/IF: Use at an assay dependent dilution(1:100-1000).
                                                        IHC-Fr: 1:100-1000.                                                    

                                                        WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 48 kDa).                                       

                                                        Not yet tested in other applications.
                                                        Optimal dilutions/concentrations should be determined by the end user. 

Function	Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Tissue specificity	Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Involvement in disease	Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
Sequence similarities	Belongs to the serpin family.
Domain	The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Cellular localization	Secreted.

AACT (H-50): Western blot analysis of AACT expression in T98G whole cell lysate.