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| Products >> Antibodies、Peptides >> Primary antibodies |
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| Anti-AAK1 antibody crn-0033R |
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- Product ID crn-0033R
- Product name Anti-AAK1 antibody
- Product Price 100µg $ 320
Immunogen KLH conjugated synthetic peptide derived from human AAK1 C-terminus.
- Reacts with hu, rat, mo
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Raised in |
Rabbit |
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Clonality |
Polyclonal |
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Isotype |
IgG |
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Purity |
Immunogen affinity purified |
- Storage buffer Preservative: 0.02% Sodium Azide
- Constituents: 1% BSA, PBS, pH 7.4
- Form Lyophilized or Liquid
Concentration 1.000 mg/ml
Recommended dilutions ELISA: Use at an assay dependent dilution(1:1000-5000) .
ICC: Use at an assay dependent dilution(1:50-500).
ICC/IF: Use at an assay dependent dilution(1:100-1000).
IHC-Fr: 1:100-1000.
- WB: Use at a concentration of 1 - 2 µg/ml. Predicted molecular weight: 94 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- The phosphorylation and dephosphorylation of proteins on serine and threonine
residues is an essential means of regulating a broad range of cellular
functions in eukaryotes, including cell division, homeostasis and apoptosis.
A group of proteins that are intimately involved in this process are the serine/
threonine (Ser/Thr) protein kinases. AAK1 (AP2 associated kinase 1) is
Bachground an 863 amino acid peripheral membrane protein that contains one protein
kinase domain and belongs to the Ser/Thr protein kinase family. Stimulated
by clathrin, AAK1 functions to catalyze the ATP-dependent phosphorylation
of the AP-2μ1 subunit of the adaptor protein complex and is thought to play
an important role in both the sorting of signals found in membrane-bound
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Sequence similarities |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain. |
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Post-translational
modifications |
Autophosphorylated. |
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Cellular localization |
Membrane. Cell membrane. Membrane > clathrin-coated pit. Active when found in clathrin-coated pits at the plasma membrane | receptors and in subsequent receptor endocytosis. Multiple isoforms of AAK1 |
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