产品描述 概述Recombinant Human Neuronal Acetylcholine Receptor Subunit α-5/NACHRA5 is produced by our Mammalian expression system and the target gene encoding Arg23-Thr254 is expressed with a 6His tag at the C-terminus. 使用说明This material is offered by Novin Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. 技术规格| Tag | C-6His | | 种属 | Human | | 表达系统 | Human Cells | | Accession# | P30532 | | Source | Human Cells | | Formulation_Description | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. | | Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. | | Reconstitution | Dissolve the lyophilized protein in distilled water. | | Purity | Greater than 90% as determined by reducing SDS-PAGE. | | Endotoxin | Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test. | | Background | Neuronal Acetylcholine Receptor Subunit α-5 (NACHRA5) is a member of the ligand-gated ion channel family. Neuronal AChR is composed of two different type of subunits: α and non-α. When NACHRA5 binds to acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits, leading to the opening of an ion-conducting channel across the plasma membrane. Genetic variations in NACHRA5 have been related to susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3. |
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