中文名称

河豚毒素单克隆抗体

别    名

TETRODOTOXIN;   Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]   pyrimidine-4,7,10,11,12-pentol  

抗体来源

Mouse

克隆类型

Monoclonal

产品应用

ELISA=1:500-1000  
  not yet tested in other applications.
  optimal dilutions/concentrations should be determined by the end user.

分 子 量

0.31927kDa

性    状

Liquid or Solid

浓    度

1mg/ml

免 疫 原

KLH conjugated to TTX

亚    型

IgG

纯化方法

affinity purified by Protein G

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03%   Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated   freeze/thaw cycles.

PubMed

PubMed

产品介绍

Tetrodotoxin, frequently abbreviated   as TTX, is a potent neurotoxin with no known antidote. There have been   successful tests of a possible antidote in mice, but further tests must be   carried out to determine efficacy in humans. Fampridine has been shown to   reverse tetrodotoxin toxicity in animal experiments.
  Tetrodotoxin blocks action potentials in nerves by binding to the   voltage-gated, fast sodium channels in nerve cell membranes, essentially   preventing any affected nerve cells from firing by blocking the channels used   in the process. The binding site of this toxin is located at the pore opening   of the voltage-gated Na+ channel. Its name derives from Tetraodontiformes, an   order that includes pufferfish, porcupinefish, ocean sunfish or mola, and   triggerfish, several species that carry the toxin. Although tetrodotoxin was   discovered in these fish and found in several other animals (e.g.,   blue-ringed octopus, rough-skinned newt, and Naticidae) it is actually   produced by certain symbiotic bacteria, such as Pseudoalteromonas   tetraodonis, certain species of Pseudomonas and Vibrio, as well as some   others that reside within these animals.
 
  SWISS:
  N/A
 
  CAS:
  4368-28-9
 
  Important   Note:
  This product as supplied is intended for research use only, not for use in   human, therapeutic or diagnostic applications.