中文名称

神经节苷酯抗体

别    名

GM1 ganglioside; Monosialoanglioside;   ganglioside GM1.  

抗体来源

Rabbit

克隆类型

Polyclonal

交叉反应

Rat,  (predicted:   Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Guinea   Pig, )

产品应用

ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2μg/Test IF=1:100-500 （石蜡切片需做抗原修复） 
  not yet tested in other applications.
  optimal dilutions/concentrations should be determined by the end user.

分 子 量

1.57kDa

细胞定位

细胞浆 细胞膜 

性    状

Liquid or Solid

浓    度

1mg/ml

免 疫 原

KLH conjugated ganglioside GM1   purified from bovine: 

亚    型

IgG

纯化方法

affinity purified by Protein A

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03%   Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated   freeze/thaw cycles.

PubMed

PubMed

产品介绍

A member of the family of   glycosphingolipids, monosialoanglioside acts as a receptor and antigen for   cholera. GM1 ganglioside, one of the glycosphingolipids widely distributed in   all tissues, occurs in highest concentrations in the central nervous system   (CNS). It is primarily located in the outer surface of the mammalian cell's   plasma membrane and in synaptic membranes of the CNS. GM1 ganglioside   modulates a number of cell surface and receptor activities as well as   neuronal differentiation and development, protein phosphorilation and   synaptic function.
 
  Subcellular   Location:
  Plasma membrane
 
  SWISS:
  N/A
 
  CAS:
  37758-47-7
 
  Important   Note:
  This product as supplied is intended for research use only, not for use in   human, therapeutic or diagnostic applications. 
 
  含有唾液酸的鞘脂类。克伦克（E.Klenk，1935）首先发现在患Tay－sachs病（泰萨氏幼年型黑白痴病）的小儿脑中有蓄积（Tag－Sachs gangli-oside），在脑灰白质中含量很多，所以对这类糖脂命名为神经节苷脂。已知糖部分是由己糖、氨基糖、唾液酸组成的脑神经节苷脂有8种以上。由山川民夫（1951）在马血球基质中找到的非神经系统的神经节苷脂——主要是血苷脂[hematoside，结构为神经酰胺（1←1β）GLc（4←1β）Gal（3←2α）唾液酸]。神经节苷脂较多地存在于细胞膜，以其与膜功能的关系被引起重视。破伤风菌和霍乱菌的外毒素可与特定的神经节苷脂分子特异性结合。在水和有机溶剂中可溶。在水中是以数百万个分子聚合的微团状态存在。
  神经节苷脂对神经再生有重大促进作用。加拿大金爵集团脑科学研究室首席科学家Gatte Walker博士进一步研究发现，神经生长因子（NGF）和神经节苷脂（GM）是脑神经再生发育必需物质，GM介导NGF数十倍增强其活性，形成新的丰富的神经网络，修复并促使脑神经再次发育。
  GM能够介导神经生长因子NGF促进脑神经细胞再生，表现出良好的生物效应。——《西安交通医科大学学报》