中文名称

还原型辅酶Ⅱ/磷酸酰胺腺嘌呤二核苷酸抗体

别    名

nicotinamide adenine dinucleotide   phosphate; NADP; NADPH; TPNH; Triphosphopyridine nucleotide, reduced form;     

抗体来源

Rabbit

克隆类型

Polyclonal

产品应用

ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
  not yet tested in other applications.
  optimal dilutions/concentrations should be determined by the end user.

分 子 量

0.833kDa

性    状

Liquid or Solid

浓    度

1mg/ml

免 疫 原

KLH conjugated NADPH: 

亚    型

IgG

纯化方法

affinity purified by Protein A

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03%   Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated   freeze/thaw cycles.

PubMed

PubMed

产品介绍

NDAPH (nicotinamide adenine   dinucleotide phosphate) includes of Alpha-NADPH and Beta-NADPH. Beta-NADPH   hase activity only. Beta-Nicotinamide adenine dinucleotide 2'-phosphate   reduced tetrasodium salt or triphosphopyridine nucleotide reduced tetrasodium   salt, also known as Coenzyme Ⅱ.
  β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide   adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox   pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation   reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer   in anabolic reactions such as lipid and cholesterol biosynthesis and fatty   acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of   antioxidation mechanism where it protects agains reactive oxidation species   accumulation. NADPH is generated in vivio by the pentose phosphate pathway   (PPP). 
 
  SWISS:
  N/A
 
  CAS:
  2646-71-1
 
  Important   Note:
  This product as supplied is intended for research use only, not for use in   human, therapeutic or diagnostic applications. 
 
  NADPH氧化酶广泛存在于机体多个系统发挥重要的生理功能。在多种病理情况下，NADPH氧化酶可以在很多组织中催化合成大量活性氧，导致过度氧化应激，使组织细胞的功能下降。
  NADPH氧化酶也是血管内皮细胞ROS产生的主要酶系,由其介导产生ROS在信息传递、基因转录、细胞生长和凋亡以及调节内皮依赖性的一氧化氮合酶脱偶联等血管舒张中的作用,使其成为血管生物学中重要的部分,NADPH氧化酶一方面与血管舒张的机能异常有关，另一方面又影响到内皮细胞的结构、粘附分子的表达、渗透、成长及迁移等功能。