中文名称

普兰林肽<降血糖药>抗体

别    名

Symlin; Pramlintideacetate;   Pramlintide, Acetate; 151126-32-8;  

抗体来源

Rabbit

克隆类型

Polyclonal

产品应用

ELISA=1:5000-10000  
  not yet tested in other applications.
  optimal dilutions/concentrations should be determined by the end user.

分 子 量

3.951kDa

性    状

Liquid or Solid

浓    度

1mg/1ml

免 疫 原

KLH conjugated synthetic peptide of   Pramlintide: 

亚    型

IgG

纯化方法

affinity purified by Protein A

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03%   Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated   freeze/thaw cycles.

PubMed

PubMed

产品介绍

Pramlintide is an analogue of amylin,   a small peptide hormone that is released into the bloodstream by the β cells   of the pancreas along with insulin after a meal. Like insulin, amylin is   completely absent in individuals with Type I diabetes. In synergy with   endogenous amylin, pramlintide aids in the regulation of blood glucose by   slowing gastric emptying, promoting satiety via hypothalamic receptors   (different receptors than for GLP-1), and inhibiting inappropriate secretion   of glucagon, a catabolic hormone that opposes the effects of insulin and   amylin. Pramlintide also has effects in raising the acute first-phase insulin   response threshold following a meal. Both a reduction in glycated hemoglobin   and weight loss have been shown in insulin-treated patients with type 2   diabetes taking pramlintide as an adjunctive therapy.
 
  SWISS:
  ?
 
  CAS:
  151126-32-8
 
  Important   Note:
  This product as supplied is intended for research use only, not for use in   human, therapeutic or diagnostic applications.