中文名称

抗利尿激素/血管升压素/加压素/血管加压素抗体

别    名

Vasopressin; Antidiuretic Hormone;   Arginine Vasopressin; ADH; Arginine vasopressin neurophysin II; ARVP; AVP;   AVP NPII; AVRP; Vasopressin neurophysin 2 copeptin precursor; Vasopressin   neurophysin II copeptin; VP; NEU2_HUMAN.  

抗体来源

Rabbit

克隆类型

Polyclonal

交叉反应

(predicted: Human, )

产品应用

ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
  not yet tested in other applications.
  optimal dilutions/concentrations should be determined by the end user.

分 子 量

1.084/15kDa

细胞定位

分泌型蛋白 

性    状

Liquid or Solid

浓    度

1mg/1ml

免 疫 原

KLH conjugated Arginine vasopressin   :CYFQNCPRG-NH₂ (Disulfide bond 1,6) 

亚    型

IgG

纯化方法

affinity purified by Protein A

储 存 液

0.01M TBS(pH7.4) with 1% BSA, 0.03%   Proclin300 and 50% Glycerol.

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated   freeze/thaw cycles.

PubMed

PubMed

产品介绍

Vasopressin, also known as arginine   vasopressin (AVP) or antidiuretic hormone (ADH), is a posterior pituitary   hormone that is synthesised in the hypothalamus. Vasopressin is synthesised   as a precursor protein that consists of arginine vasopressin and two associated   proteins, neurophysin 2 and the glycopeptide copeptin. Vasopressin, together   with its carrier protein neurophysin II, is packaged into neurosecretory   vesicles and transported axonally to the nerve endings in the   neurohypophysis, where it is either stored or secreted into the bloodstream.   Vasopressin acts as a growth factor by enhancing pH regulation through   acid-base transport systems. It has a direct antidiuretic action on the   kidney and also causes vasoconstriction of the peripheral vessels. Vasopressin   can also contract smooth muscle during parturition and lactation. It also   plays a role in cognition, tolerance, adaptation and complex sexual and   maternal behaviour, as well as in the regulation of water excretion and   cardiovascular functions. Mutations in the vasopressin precursor cause   autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is   characterised by persistant thirst, polydipsia and polyuria.
 
  Function:
  Neurophysin 2 specifically binds vasopressin. 
  Vasopressin has a direct antidiuretic action on the kidney, it also causes   vasoconstriction of the peripheral vessels.
 
  Subcellular   Location:
  Secreted.
 
  DISEASE:
  Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes   insipidus (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst,   polydipsia and polyuria. The disease is transmitted in an autosomal dominant   mode and appears to be largely if not completely penetrant. 
  Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes   insipidus (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst,   polydipsia and polyuria. Most mutations are hypothesized to trigger   neurodegeneration via disruption of preproAVP-NPII processing.
 
  Similarity:
  Belongs to the vasopressin/oxytocin family.
 
  SWISS:
  P01185
 
  CAS:
  551
 
  Database   links:

Entrez Gene: 551 Human

Omim:   192340 Human

SwissProt:   P01185 Human

Unigene: 89648 Human

   Important   Note:
  This product as supplied is intended for research use only, not for use in   human, therapeutic or diagnostic applications.